ncRNA name | NDPKB siRNA |
ncRNA Category | siRNA |
Disease name | diabetic retinopathy (DR) |
Species | Homo sapiens |
Tissues/Cell_line | human umbilical vein endothelial cells (HUVECs) |
Methods | quantitative retinal morphometry, siRNA transfection, immunoblot, immunofluorescence |
Expression pattern | associated |
Functional description | Our data identify NDPKB as a protective factor in the retina, which controls Ang2 expression and the hexosamine pathway. NDPKB depletion comparably increased Ang2 expression and protein GlcNAcylation. |
PubMed ID | 25900369 |
Year | 2016 |
Title | Nucleoside diphosphate kinase B deficiency causes a diabetes-like vascular pathology via up-regulation of endothelial angiopoietin-2 in the retina. |
Drug-related ncRNA | NO |
Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.