logo

        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic retinopathy (DR)
ncRNA name NDPKB siRNA
ncRNA Category siRNA
Disease name diabetic retinopathy (DR)
Species Homo sapiens
Tissues/Cell_line human umbilical vein endothelial cells (HUVECs)
Methods quantitative retinal morphometry, siRNA transfection, immunoblot, immunofluorescence
Expression pattern associated
Functional description Our data identify NDPKB as a protective factor in the retina, which controls Ang2 expression and the hexosamine pathway. NDPKB depletion comparably increased Ang2 expression and protein GlcNAcylation.
PubMed ID 25900369
Year 2016
Title Nucleoside diphosphate kinase B deficiency causes a diabetes-like vascular pathology via up-regulation of endothelial angiopoietin-2 in the retina.
Drug-related ncRNA NO

Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.